Endocrine Abstracts

BackgroundPrimary hyperparathyroidism (PHPT) results from inappropriate overproduction of parathyroid hormone from one or more of parathyroid glands with consequent hypercalcemia. Medical therapy by bisphosphonates is indicated for patients contraindicated for surgical treatment or those with therapy failure. We report the observation of a patient receiving zoledronic acid for persistent PHPT and who developped bisphosphonate-related osteonecrosis of the...

IntroductionPheochromocytoma is rare neuroendocrine tumor arising from the chromaffin cells of the adrenal medulla. It can be even sporadic or take part of inherited syndromes.ObservationWe report the case of a young 32 year-old woman followed by her oncologist for medullary thyroid cancer treated with surgery and radiotherapy. On the examination of the removed tissue, there was a bilateral cancer, measuring ...

IntroductionAutoimmune polyglandular syndrome (APS) is a rare endocrinopathy, characterized by the coexistence of two or more glandular autoimmune diseases that can appear at different intervals of time.ObservationHerein the case of a young woman descendant of first degree consanguineous marriage, diagnosed since the age of six with celiac disease (CD) where gluten-free diet was not respected due to poor soci...

IntroductionAs hypoglycemia is a common symptom, an organic cause is always the first diagnosis looked for as it can be associated with a specific medical or surgical treatment. Diagnosis of functional etiology isn’t as precise, as the whipple triad can be incomplete. We herein report a serie of confirmed etiology for functional hypoglycemia.MethodsThis is a descriptive retrospective study including 20 c...

IntroductionPrimary amenorrhea should be considered in any patient who has not experienced periodic menstruation by 16 years regardless of the presence of normal growth and development of secondary sexual characteristics.Observation17-year-old patient, who exhibited normal secondary sexual characteristics, normal auxiliary and pubic hairs, normal breast development since the age of 12 with the non-appearance ...

IntroductionGrave’s disease is an autoimmune disease characterized by hyperthyroidism. It is in some cases associated to more autoimmune organs dysfunction. The antithyroid drugs are the first line treatement, and sometimes they are responsible for severe adverse effects.ObservationWe report the case of a 34 year-old man, treated for his grave’s disease with thiamazol for two years. Two weeks after ...

Introduction: Wilson’s disease is a rare and serious genetic disorder. The accumulation of copper in glands causes several endocrine pathologies. Herein, we report a rare case of hypophysitis with corticotropic deficiency caused by Wilson’s disease.Observation: A 33-years-old female patient was referred to the endocrinology department for hypoglycemia. She had a history of Wilson’s disease diagnosed at the age of nine complicated by cirrho...

Introduction: Isolated hypogonadotropic hypogonadism is a heterogeneous group of genetic abnormalities affecting the hypothalamic pituitary gonadal axis. The main mechanism consists of an impairment of the production or the action of gonadotropin releasing hormone (GnRH). While several mutations have been identified, the majority of cases remain without etiology. The objective of our study was to describe the clinical and biological profiles of these diseases.<p class="abs...

Introduction: Thyroid eye disease (TED) is an autoimmune inflammatory disorder affecting the orbital tissues. It occurs with thyroid dysfunction notably Graves’ disease. TED exhibits different severity patterns and has a lot of risk factors. We, herein, report a rare case of a severe TED developing after COVID-19 infection in a patient initially treated for hyperthyroidism without ocular manifestations.Observation: A 48-year-old female with a histor...

Introduction: Homeostasis of calcium and phosphor influence bone metabolism. They depend on several hormones, including parathyroid hormone, thyroid and sexual hormones. Low bone mass seems a common issue in endocrine disorders. The aim of this study is to identify the different endocrine disorders in patients with low bone mass.Methods: Retrospective study collecting the medical files of patients followed in the endocrinology department of Charles Nicol...